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Updated: Apr 3, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Transient relay function of midline thalamic nuclei during long-term memory consolidation in humans
Jan-Willem Thielen1, Atsuko Takashima2, Femke Rutters3
1Donders Institute for Brain Cognition and Behavior, Radboud University Medical Center, 6537 Nijmegen, The Netherlands Department for Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, 45127 Essen, Germany Erwin L. Hahn Institute for Magnetic Resonance Imaging, 45127 Essen, Germany jan-willem.thielen@uni-due.de.
Abstract:
To test the hypothesis that thalamic midline nuclei play a transient role in memory consolidation, we reanalyzed a prospective functional MRI study, contrasting recent and progressively more remote memory retrieval. We revealed a transient thalamic connectivity increase with the hippocampus, the medial prefrontal cortex (mPFC), and a parahippocampal area, which decreased with time. In turn, mPFC-parahippocampal connectivity increased progressively. These findings support a model in which thalamic midline nuclei serve as a hub linking hippocampus, mPFC, and posterior representational areas during memory retrieval at an early (2 h) stage of consolidation, extending classical systems consolidation models by attributing a transient role to midline thalamic nuclei.
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