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The skin barrier function: differences between intrinsic and extrinsic aging.

C Trojahn1, G Dobos, U Blume-Peytavi

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Summary
This summary is machine-generated.

Skin barrier function shows minor changes in transepidermal water loss (TEWL) and stratum corneum hydration (SCH) with age, but skin surface pH increases significantly. Photodamage effects on skin aging were not clearly evident.

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Area of Science:

  • Dermatology
  • Skin Physiology
  • Aging Research

Background:

  • Skin barrier function is crucial for maintaining skin health.
  • Key parameters include transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin surface pH.
  • Assessing these parameters helps understand skin aging and the effects of environmental factors like sun exposure.

Purpose of the Study:

  • To compare TEWL, SCH, and skin surface pH on sun-protected versus sun-exposed skin areas.
  • To investigate the influence of age on these skin barrier parameters.
  • To explore potential differences between intrinsically and extrinsically aged skin.

Main Methods:

  • Twenty-four healthy female subjects were divided into three age groups.
  • Lifetime sun exposure was assessed via questionnaire.
  • TEWL, SCH, and skin surface pH were measured on the upper inner arm, volar forearm, and dorsal forearm under standardized conditions.

Main Results:

  • No significant differences in TEWL were found between age groups across skin areas.
  • TEWL was significantly lower on the dorsal forearm compared to other sites.
  • Stratum corneum hydration (SCH) showed higher values on the volar forearm, with no significant age-related differences.
  • Skin surface pH increased significantly with age on the upper inner arm and was lower on the dorsal forearm compared to the upper inner arm.

Conclusions:

  • Skin barrier function exhibits minor age-related changes in TEWL and SCH.
  • A notable increase in skin surface pH occurs with aging.
  • While differences exist between sun-protected and sun-exposed areas, the study found no clear evidence of photodamage impairing the skin barrier function.