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Bordetella pertussis transmission

Elizabeth A Trainor1, Tracy L Nicholson2, Tod J Merkel3

  • 1Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.

Pathogens and Disease
|September 17, 2015
PubMed

Insights

Animal models advance understanding of Bordetella pertussis transmission. Studies using baboon, swine, and mouse models reveal insights into whooping cough spread, bacterial factors, and vaccine impacts.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pathogen Transmission

Background:

  • Bordetella pertussis causes whooping cough and is a human-adapted variant of Bordetella bronchiseptica.
  • Both Gram-negative bacteria are closely related genetically and share pathogenesis mechanisms.
  • Despite genetic similarity, they exhibit distinct host ranges, pathologies, and persistence.

Purpose of the Study:

  • To review B. pertussis transmission dynamics.
  • To highlight the contribution of animal models to understanding B. pertussis transmission.
  • To explore how B. bronchiseptica models inform B. pertussis transmission research.

Main Methods:

  • Review of existing literature on B. pertussis and B. bronchiseptica transmission.
  • Analysis of data from established animal models (baboon, swine, mouse).
  • Investigation of transmission routes, attack rates, host/bacterial factors, and vaccination effects.

Main Results:

  • Development of baboon, swine, and mouse models has facilitated transmission studies.
  • These models allow detailed examination of transmission routes and contributing factors.
  • Vaccination's impact on transmission can be effectively studied in these models.

Conclusions:

  • Animal models are crucial for elucidating B. pertussis transmission.
  • Comparative studies with B. bronchiseptica models enhance understanding of pertussis transmission.
  • Further research using these models will improve control strategies for whooping cough.
Keywords:
Animal modelsBordetella bronchisepticaBordetella pertussisWhooping coughaerosol transmission

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