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New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
Jia-Lin Li1, Na Li1, Shan-Shan Xing1
1College of Pharmacy, Beihua University, Jilin City, 132013, Jilin Province, People's Republic of China.
Abstract:
New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 ± 1.4 µM.
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