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Related Experiment Video

Updated: Apr 3, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Cognitive function in idiopathic pulmonary fibrosis.

Melinda Bors¹, Rade Tomic², David M Perlman²

¹Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota Health, Minneapolis, MN, USA borsx002@umn.edu.

Chronic Respiratory Disease

|September 17, 2015

Summary

Individuals with severe idiopathic pulmonary fibrosis (IPF) experience cognitive deficits, including slower processing speeds and impaired divided attention, compared to those with mild IPF or healthy lungs. Further research is needed to understand and address these cognitive impairments.

Keywords:

HRQOL Interstitial lung disease cognitive impairment idiopathic pulmonary fibrosis (IPF)

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Neurology
Pulmonology
Psychology

Background:

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease.
Cognitive function in IPF patients is not well understood.
Investigating cognitive deficits in severe IPF is crucial for patient care.

Purpose of the Study:

To determine if severe idiopathic pulmonary fibrosis (IPF) is associated with cognitive deficits.
To compare cognitive performance in severe IPF patients versus mild-to-moderate IPF patients and healthy controls.

Main Methods:

Neuropsychological tests including Trail Making Test (TMT) A and B, Stroop Color Word Test, Hopkins Verbal Learning Test, Boston Naming Test, and Grooved Pegboard Test were administered.
Short Form-36 (SF-36) and Beck Depression Index were also used.
Participants included severe IPF (DLCO <30%), mild-to-moderate IPF (DLCO >30%), and healthy control groups.

Main Results:

Severe IPF patients exhibited significantly longer TMT B times, indicating deficits in divided attention and processing speed.
The severe IPF group also showed significantly lower scores on the Stroop 3 test, suggesting impaired processing speed and response inhibition.
Cognitive function was significantly worse in the severe IPF group compared to both mild-to-moderate IPF and control groups.

Conclusions:

Severe IPF is associated with significant cognitive deficits.
These deficits may impact daily functioning and quality of life for IPF patients.
Further research is warranted to elucidate the mechanisms behind these cognitive impairments and to develop targeted interventions.