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Published on: March 27, 2018
Morphological Variants of Renal Carcinoma in Radical Nephrectomy Specimens
Humera1, Shahzad Ali2, Shahnaz Imdad Kehar1
1Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi.
Objective:
To determine the morphological variants of Renal Cell Carcinoma (RCC) to detect the commonest histopathological type with special focus to the newly introduced entity Clear Cell Papillary Renal Cell Carcinoma (CCPRCC).
Study Design:
Case series.
Place And Duration Of Study:
Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi, from January 2007 to December 2012.
Methodology:
Paraffin embedded blocks of 32 cases of radical nephrectomy specimens for renal mass were selected from records of Pathology Department, BMSI. Cases were excluded due to inadequate biopsies. Remaining 30 cases of renal cell carcinoma were included in study. H & E staining was done for all cases and PAS stain was employed for a few cases. All cases were reviewed under light microscope.
Results:
The 30 cases of renal cell carcinoma included 21 (70%) clear cell renal cell carcinoma, 03 (10%) clear cell papillary renal cell carcinoma, 02 (6.6%) papillary renal cell carcinoma and 04 (13.33%) hybrid tumors. Majority of cases (53.3%) found in age range between 40 - 60 years while 23.33% cases were found in 7th and 6.6% in 8th decade of life. While 16.66% cases were in younger age group that is between 31 - 40 years of age. Sixty percent cases of right radical nephrectomies and 40% cases of left radical nephrectomies.
Conclusion:
CCRCC was most common histopathologic type followed by CCPRCC, hybrid tumors and PRCC.
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