Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

11.2K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
11.2K
Apoptosis01:30

Apoptosis

17.0K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
17.0K
Autophagic Cell Death01:18

Autophagic Cell Death

5.0K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
5.0K
Necrosis01:16

Necrosis

7.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
7.3K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

9.3K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
9.3K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

4.1K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Memoriam: Dmitri Krysko.

Apoptosis : an international journal on programmed cell death·2026
Same author

The 340B Drug Pricing Program, Hospital Prices, and Competition in Commercial Markets.

Health services research·2026
Same author

Missing School Matters for Children's Health: Multidisciplinary Approaches to Chronic Absenteeism and Its Socioeconomic Drivers.

The Journal of pediatrics·2026
Same author

Compressive pangenomics using mutation-annotated networks.

Nature genetics·2026
Same author

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape.

bioRxiv : the preprint server for biology·2025
Same author

Corrigendum to "CEPO-Fc (An EPO Derivative) protects hippocampus against Aβ-induced memory deterioration: a behavioral and molecular study in a rat model of Aβ toxicity". [Neuroscience 388 (2018) 405-417].

Neuroscience·2025
Same journal

Spatiotemporal dynamics of lineage-specific epithelial maturation in the developing mouse stomach.

The International journal of developmental biology·2026
Same journal

Dynein axonemal assembly factors (<i>dnaaf</i>) 5 and 9 are expressed in ciliated organs of zebrafish embryos.

The International journal of developmental biology·2026
Same journal

A chloroquine sensitivity gradient induces tissue regeneration and maintenance phenotypes in planarians.

The International journal of developmental biology·2026
Same journal

Sialylated glycoproteins and sialyltransferases involved in mesoderm-derived organ formation during embryogenesis.

The International journal of developmental biology·2026
Same journal

The <i>Hydra</i> FGF family - dispersed across the genome and expressed locally.

The International journal of developmental biology·2026
Same journal

Correction: Inhibition of COX2 impairs angiogenesis and causes vascular defects in developing zebrafish embryos.

The International journal of developmental biology·2025
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.1K

What cell death does in development.

Zahra Zakeri1, Carlos G Penaloza, Kyle Smith

  • 1College and Graduate Center, Department of Biology, City University of New York, NY. zahra_zakeri@hotmail.com.

The International Journal of Developmental Biology
|September 17, 2015
PubMed
Summary
This summary is machine-generated.

Cell death is crucial for embryonic development, particularly in mammals where it aids in cell differentiation and organogenesis. Understanding the communication pathways that trigger programmed cell death is essential for developmental biology.

More Related Videos

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.6K
Author Spotlight: THP-1 Macrophage Response to LPS/ATP &#8212; Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

3.7K

Related Experiment Videos

Last Updated: Apr 3, 2026

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.1K
In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.6K
Author Spotlight: THP-1 Macrophage Response to LPS/ATP &#8212; Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

3.7K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Cell death plays a significant role in gametogenesis and embryonic sculpting.
  • While common in non-mammalian embryos post-maternal-zygotic transition, cell death in mammalian embryos is critical during compaction for trophoblast and inner cell mass separation.
  • Massive cell overproduction followed by selection, involving cell death, is essential for generating correct cell numbers in organs like the CNS and immune system.

Purpose of the Study:

  • To explore the role and mechanisms of programmed cell death in embryonic development across different species.
  • To investigate the genetic control and timing of cell death during embryogenesis.
  • To understand the implications of aberrant cell death in developmental phenotypes.

Main Methods:

  • Review and synthesis of existing literature on cell death in embryogenesis.
  • Analysis of studies documenting cell death patterns using apoptosis-recognition techniques.
  • Examination of methods identifying lysosomes to reveal cell death patterns.

Main Results:

  • Cell death is prominent in mammalian embryonic development, particularly during compaction and organogenesis.
  • While the genetic control of cell death is well-defined in model organisms like Caenorhabditis elegans, its stochastic nature in other embryos complicates precise identification of dying cells.
  • Disrupting cell death machinery can be lethal, yet mutations in regulatory mechanisms often show redundancy and compensatory effects, leading to modest or no observable phenotypes.
  • Apoptotic cell death is the predominant form, but lysosome-identifying techniques also reveal cell death patterns.
  • Aberrant cell deaths are typically localized, suggesting regional activation of programmed death pathways is key.

Conclusions:

  • Programmed cell death is a fundamental process shaping embryonic development, essential for tissue sculpting and organogenesis.
  • Significant redundancy and compensation exist within cell death regulatory mechanisms.
  • Further research is needed to elucidate the intercellular communication networks that initiate programmed cell death during embryogenesis.