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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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Immunogenic cell death

Abhishek D Garg1, Aleksandra M Dudek-Peric, Erminia Romano

  • 1Cell Death Research and Therapy (CDRT) Laboratory, Department for Cellular and Molecular Medicine, KULeuven University of Leuven, Leuven, Belgium.

The International Journal of Developmental Biology
|September 17, 2015
PubMed

Insights

Cancer cells can evade immune responses by reducing their immunogenicity. Inducing immunogenic cell death (ICD) enhances cancer cell visibility to the immune system, promoting anticancer immunity.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Anticancer immunosurveillance normally rejects early neoplastic lesions.
  • Aggressive cancers with high mutational diversity can evade immune detection.
  • Low immunogenicity is a key mechanism for cancer immune evasion.

Purpose of the Study:

  • To introduce and detail the concept of immunogenic cell death (ICD).
  • To discuss the characteristics of ICD.
  • To explore the determinants of ICD.

Main Methods:

  • Review of current scientific literature on cancer immunology and cell death.
  • Detailed analysis of molecular and immunological pathways involved in ICD.
  • Discussion of operational aspects of inducing ICD.

Main Results:

  • Immunogenic cell death (ICD) involves cancer cell death pathways that activate danger signaling.
  • ICD triggers the release of damage-associated molecular patterns (DAMPs).
  • ICD significantly enhances the immunogenicity of dying cancer cells.

Conclusions:

  • ICD represents a promising strategy to overcome cancer immune evasion.
  • Understanding ICD determinants is crucial for developing effective cancer immunotherapies.
  • Targeting ICD can potentially restore and stabilize anticancer immunity.

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