Related Experiment Video
Updated: Apr 3, 2026
Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification
Published on: August 1, 2025
Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial
Erhan Aysan1, Burcugul Altug, Cilem Ercan
1From the Department of General Surgery, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
Objectives:
Parathyroid allotransplant is a valuable alternative in treating permanent hypoparathyroidism. However, it is a difficult process that requires several trained staff and advanced laboratory equipment, which makes the costs high. Here, we identify a new parathyroid allotransplant technique.
Materials And Methods:
After obtaining informed consent from patients, parathyroid cell suspensions obtained from 4 donors who had undergone a subtotal parathyroidectomy owing to chronic renal failure were transplanted in 10 patients with permanent hypoparathyroidism after short-term cell cultivation. Prednisolone were used as immunosuppressant for the first 10 days and discontinued thereafter.
Results:
Allograft function was observed in 7 patients (70%) at a mean follow-up of 12 months. Daily oral calcium and vitamin D supplementations discontinued totally in 7 patients. No major or minor complication was observed.
Conclusions:
Our technique is simple, fast, and has a low cost, with a 70% success rate at a mean follow-up of 12 months. It requires few staff, minimal equipment, and short-term immunosuppressant use for maintenance. The technical developments of parathyroid allotransplant, as mentioned in this study, may be important in treating permanent hypoparathyroidism.
