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Systematic Review of Brain Tumor Treatment in Dogs
H Hu1, A Barker2, T Harcourt-Brown3
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA.
Journal of Veterinary Internal Medicine
|September 17, 2015
Summary
Formal comparisons of canine intracranial neoplasia treatments are lacking. This review found no clear outcome difference between surgery and radiotherapy, but lomustine showed no efficacy for brain tumors in dogs.
Area of Science:
- Veterinary Neurology
- Comparative Oncology
- Canine Medicine
Background:
- Intracranial neoplasia is a common diagnosis in dogs.
- Various treatment modalities exist, but efficacy comparisons are limited.
- Optimal treatment recommendations for canine brain tumors are needed.
Purpose of the Study:
- To systematically review and summarize treatment outcomes for intracranial masses in dogs.
- To identify optimal treatment recommendations for canine brain tumor patients.
- To highlight the need for standardized study designs in canine neuro-oncology.
Main Methods:
- Systematic review following PRISMA guidelines.
- Literature search of Pubmed for relevant studies.
- Analysis of 794 cases from 22 published reports.
- Data extraction and synthesis of treatment outcomes.
Main Results:
- High heterogeneity among studies regarding inclusion criteria, survival definitions, and follow-up.
- Available data do not support lomustine as an effective treatment for canine brain tumors.
- No clear difference in outcome was observed between radiotherapy and surgery when both were options.
Conclusions:
- Standardized study design and outcome reporting are crucial for canine brain tumor research.
- Current evidence is insufficient to definitively recommend one surgical or radiation approach over another.
- Further high-quality research is needed to establish evidence-based treatment guidelines for intracranial neoplasia in dogs.
