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Probiotics and chronic kidney disease.
Laetitia Koppe1, Denise Mafra2, Denis Fouque1
1Department of Nephrology and Nutrition, Centre Hospitalier Lyon SUD, Carmen, CENS, Univ Lyon, UCBL, Pierre Bénite, France.
Kidney International
|September 17, 2015
Summary
Probiotics show promise for managing chronic kidney disease (CKD) by targeting gut microbiota and reducing uremic toxins. Further high-quality clinical trials are needed to confirm their therapeutic potential in CKD patients.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- Intestinal microbiota dysbiosis is increasingly recognized as a key factor in chronic kidney disease (CKD) progression and complications.
- Probiotics, live microorganisms conferring health benefits, are being explored as a natural biotreatment for CKD.
- Strain-specific functional biomarkers are crucial for selecting effective probiotic interventions.
Purpose of the Study:
- To review the potential mechanisms of action and efficacy of probiotics in managing CKD.
- To emphasize the role of probiotics in reducing uremic toxin production and inflammation in CKD.
- To highlight the need for improved quality in clinical trials investigating probiotics for CKD.
Main Methods:
- Literature review of in vitro, animal, and human studies on probiotics for CKD.
- Analysis of proposed mechanisms, including modulation of intestinal microbiota and reduction of uremic toxins.
- Evaluation of the current evidence base for probiotic efficacy in CKD management.
Main Results:
- Probiotics demonstrate potential in decreasing uremic toxin production and improving renal function in preclinical and some clinical studies.
- The efficacy of probiotics is highly strain-specific, necessitating careful selection based on functional biomarkers.
- Existing clinical trials investigating probiotics for CKD often lack sufficient quality and standardization.
Conclusions:
- Probiotics represent a promising therapeutic avenue for CKD management, particularly for mitigating uremic toxin accumulation and inflammation.
- Further rigorous, high-quality clinical trials are essential to establish the definitive role and optimal application of specific probiotic strains in CKD.
- Targeting the gut-kidney axis with probiotics offers a novel strategy for improving outcomes in patients with chronic kidney disease.
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