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Focal glomerulosclerosis manifested with nephrotic syndrome.

Y K Tsau, C H Chen, W S Tsai

    Zhonghua Minguo Xiao Er Ke Yi Xue Hui Za Zhi [Journal]. Zhonghua Minguo Xiao Er Ke Yi Xue Hui
    |November 1, 1989
    PubMed
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    Long-term outcomes for children with focal glomerulosclerosis (FGS) show a generally positive prognosis. While some experience renal issues, many achieve remission, suggesting clinical outcomes are not overly pessimistic.

    Area of Science:

    • Pediatric Nephrology
    • Glomerular Diseases

    Background:

    • Focal glomerulosclerosis (FGS) is a significant cause of nephrotic syndrome in children.
    • Understanding the long-term prognosis is crucial for patient management and counseling.

    Purpose of the Study:

    • To evaluate the long-term clinical outcomes of children diagnosed with focal glomerulosclerosis (FGS).
    • To identify potential predictive factors for chronic renal failure in this pediatric population.

    Main Methods:

    • A retrospective study of 23 nephrotic children with FGS.
    • Analysis of clinical features, renal biopsy findings, steroid response, and long-term follow-up data.
    • Assessment of renal survival, creatinine clearance, proteinuria, and remission rates.

    Main Results:

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    • Of 23 children, 20 had focal segmental glomerulosclerosis (FSGS) and 3 had focal global sclerosis (FGS).
    • Hypertension and hematuria were common; glycosuria was occasional.
    • 39% achieved remission, 35% had persistent proteinuria, 13% experienced renal death, and 13% had decreased creatinine clearance.
    • None of the 3 patients with focal global sclerosis progressed to chronic renal failure.

    Conclusions:

    • The long-term clinical outcome for children with focal glomerulosclerosis (FGS) appears more favorable than previously thought.
    • No specific clinical or morphological features, except possibly glycosuria, predicted the development of chronic renal failure in this cohort.