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Focal glomerulosclerosis manifested with nephrotic syndrome.
Zhonghua Minguo Xiao Er Ke Yi Xue Hui Za Zhi [Journal]. Zhonghua Minguo Xiao Er Ke Yi Xue Hui
|November 1, 1989
Summary
Long-term outcomes for children with focal glomerulosclerosis (FGS) show a generally positive prognosis. While some experience renal issues, many achieve remission, suggesting clinical outcomes are not overly pessimistic.
Area of Science:
- Pediatric Nephrology
- Glomerular Diseases
Background:
- Focal glomerulosclerosis (FGS) is a significant cause of nephrotic syndrome in children.
- Understanding the long-term prognosis is crucial for patient management and counseling.
Purpose of the Study:
- To evaluate the long-term clinical outcomes of children diagnosed with focal glomerulosclerosis (FGS).
- To identify potential predictive factors for chronic renal failure in this pediatric population.
Main Methods:
- A retrospective study of 23 nephrotic children with FGS.
- Analysis of clinical features, renal biopsy findings, steroid response, and long-term follow-up data.
- Assessment of renal survival, creatinine clearance, proteinuria, and remission rates.
Main Results:
- Of 23 children, 20 had focal segmental glomerulosclerosis (FSGS) and 3 had focal global sclerosis (FGS).
- Hypertension and hematuria were common; glycosuria was occasional.
- 39% achieved remission, 35% had persistent proteinuria, 13% experienced renal death, and 13% had decreased creatinine clearance.
- None of the 3 patients with focal global sclerosis progressed to chronic renal failure.
Conclusions:
- The long-term clinical outcome for children with focal glomerulosclerosis (FGS) appears more favorable than previously thought.
- No specific clinical or morphological features, except possibly glycosuria, predicted the development of chronic renal failure in this cohort.