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Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold
Beatriz Domínguez-Pérez1, Éric Ferrer1, Marta Figueredo1
1Departament de Quı́mica, Universitat Autònoma de Barcelona , 08193 Bellaterra, Spain.
The Journal of Organic Chemistry
|September 17, 2015
Abstract:
A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
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