Related Experiment Video
Updated: Apr 3, 2026

08:13
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
20.4K
[Left ventricular non compaction: A poorly known cardiomyopathy].
Revue Medicale De Liege
|September 18, 2015
Summary
Left ventricular noncompaction is a rare congenital heart muscle disease. This condition causes heart failure, arrhythmias, and embolic events due to abnormal heart structure.
Area of Science:
- Cardiology
- Genetics
- Pathology
Background:
- Left ventricular noncompaction (LVNC) is a rare congenital cardiomyopathy.
- It is characterized by a specific myocardial structure with a spongy appearance.
Observation:
- Prominent trabeculations and deep intertrabecular recesses are key features.
- These recesses communicate directly with the left ventricular cavity.
Findings:
- The epicardial layer is thin and compacted.
- The endocardial layer exhibits a noncompacted, trabeculated morphology.
Implications:
- LVNC can lead to severe complications including chronic heart failure.
- Life-threatening ventricular arrhythmias and systemic embolic events are significant risks.
- Understanding LVNC's pathophysiology is crucial for diagnosis and management.
Related Concept Videos
Cardiomyopathy I: Introduction and Classification
818
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
818
Cardiomyopathy IV: Restrictive Cardiomyopathy
830
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
830
Cardiomyopathy III: Hypertrophic Cardiomyopathy
718
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
718
Cardiomyopathy II: Dilated Cardiomyopathy
769
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
769
Cardiomyopathy V: Interprofessional Care
647
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
647
Imbalances in Cardiac Output
3.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K

