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Updated: Apr 3, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
Why the Central Dogma: on the nature of the great biological exclusion principle
1National Center for Biotechnology Information, National Library of Medicine, National Instittues of Health, Bethesda, MD, 20894, USA. koonin@ncbi.nlm.nih.gov.
Abstract:
The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information.
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