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EZH2 is a sensitive marker of malignancy in salivary gland tumors
Szofia Hajósi-Kalcakosz1,2, Eszter Vincze3, Katalin Dezső1
1First Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.
Background:
The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of salivary gland tumors is a challenging task, and a reliable marker of malignancy would be extremely helpful.
Methods:
EZH2 expression was investigated in 54 malignant and 40 benign salivary gland tumors of various histological types by standard immunohistochemistry.
Results:
The majority (n = 52) of the malignant tumors stained positively, while all the investigated benign tumors were negative for EZH2.
Conclusions:
EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors.
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