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Synthesis of some pyrazoline and isoxazolin derivatives as possible fungicides
Abstract:
1-Acetyl/aroyl-3-methyl-4-substituted anilido-5-aryl pyrazolines and 3-methyl-4-substituted anilido-5-aryl isoxazolines were conveniently prepared from synthon, 4-aryl-3-substituted anilido but-3-en-2-ones in presence of hydrazine hydrate/hydrazides and hydroxylamine hydrochloride respectively. All the compounds have been assayed against Cephalosporium sacchari and Helminthosporium oryzae and found remarkably active. Two species of aquatic fungi viz. Saprolegnia parasitica and Achlya orion responsible for fish mycoses were tested and also found remarkably active.