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Growth evaluation in children with vesicoureteral reflux

Ahmet Keskinoğlu1, Şükran Darcan2, Pembe Keskinoğlu3

  • 1Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ege University, İzmir, Turkey - ahmet.keskinoglu@ege.edu.tr.

Minerva Pediatrica
|September 18, 2015
PubMed

Insights

Vesicoureteral reflux (VUR) negatively impacts child growth. Treatment improved weight gain, though height Z-scores also increased. This study evaluated growth patterns in children with VUR before and after treatment.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Urinary Tract Disorders

Background:

  • Vesicoureteral reflux (VUR) and urinary tract infections (UTIs) are linked to growth retardation, hypertension, renal scarring, and failure in children.
  • Early identification and management of VUR are crucial to mitigate long-term renal damage and growth impairment.

Purpose of the Study:

  • To investigate the growth patterns of children diagnosed with VUR.
  • To assess the impact of medical and/or surgical treatment on the growth indices of these children.

Main Methods:

  • A retrospective cross-sectional study involving 97 children (0.5-17 years) with VUR.
  • Measurement of body weight, height, and bone age; calculation of Weight Z-score and height Z-score before and after treatment.
  • Statistical analysis using T-test, Mann-Whitney U test, and Wilcoxon test.

Main Results:

  • Children with VUR often presented with negative Weight Z-scores (54.6%) and height Z-scores (50.5%).
  • Following treatment, both Weight Z-score and height Z-score showed improvement, with a statistically significant increase in Weight Z-score (P=0.039).
  • A significant reduction in bone age was observed in children with renal scars compared to those without (P=0.048).

Conclusions:

  • High-grade VUR adversely affects children's growth indices.
  • Medical or surgical interventions demonstrate a positive influence on weight gain in pediatric patients with VUR.
Abstract

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