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Updated: Apr 3, 2026

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Targeting the glucocorticoid receptor in breast and prostate cancers

Jacob Kach1, Suzanne D Conzen2, Russell Z Szmulewitz3

  • 1Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637, USA.

Science Translational Medicine
|September 18, 2015
PubMed

Insights

Glucocorticoid receptor (GR) activity is crucial in prostate and breast cancers. Its function relies on the concurrent activity of androgen or estrogen receptors within the tumor.

Area of Science:

  • Oncology
  • Molecular Endocrinology
  • Cancer Biology

Background:

  • Steroid hormone receptors, including androgen and estrogen receptors, are established drivers in prostate and breast cancers.
  • Emerging evidence suggests a significant role for glucocorticoid receptor (GR) activity in these malignancies.

Purpose of the Study:

  • To investigate the interplay between glucocorticoid receptor (GR) activity and other steroid hormone receptors in prostate and breast cancer.
  • To elucidate the cooperative mechanisms governing nuclear receptor function in cancer.

Main Methods:

  • This study focused on analyzing the functional dependence of GR in cancer cells.
  • The research examined the correlation between GR activity and the activity of androgen and estrogen receptors.

Main Results:

  • Glucocorticoid receptor (GR) function in prostate and breast cancer is not independent.
  • GR activity is contingent upon the concurrent activity of tumor-associated androgen or estrogen receptors.

Conclusions:

  • Nuclear receptor crosstalk is a critical factor in cancer progression.
  • Targeting GR in prostate and breast cancers may require consideration of concomitant androgen or estrogen receptor signaling pathways.

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