The Aging of the Global Population: The Changing Epidemiology of Disease and Spinal Disorders
Michael G Fehlings1, Lindsay Tetreault, Anick Nater
1*Division of Neurosurgery and Spine Program, Toronto Western Hospital, Canada; ‡Toronto Western Research Institute, University Health Network, Canada; Institute of Medical Science, University of Toronto, Canada; §Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri; ‖Thomas Jefferson University Hospital, Department of Neurosurgery, Philadelphia, Pennsylvania; ¶Cleveland Clinic, Cleveland, Ohio; #Department of Neurosurgery, University of Virginia, Charlottesville, Virginia.
Abstract:
The global population is currently undergoing an upward shift in its age structure due to decreasing fertility rates and increasing life expectancy. As a result, clinicians worldwide will be required to manage an increasing number of spinal disorders specific to the elderly and the aging of the spine. Elderly individuals pose unique challenges to health care systems and to spinal physicians as these patients typically have an increased number of medical comorbidities, reduced bone density mass, more severe spinal degeneration and a greater propensity to falls. In anticipation of the aging of the population, we undertook this project to heighten physicians' awareness of age-related spinal disorders, including geriatric odontoid fractures, central cord syndrome, osteoporotic compression fractures, degenerative cervical myelopathy, lumbar spinal stenosis and degenerative spinal deformity. This introductory article provides an overview of the changing demographics of the global population; discusses the age-related alterations that may occur to the spine; and summarizes the purpose and contents of this focus issue.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues
Pharmacodynamics in Geriatric Patients: Effects of Age
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption


