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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix
Ya-Yuan Lai1,2, Li-Chai Chen3,4, Chug-Fung Wu5
1Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. spire0123456@yahoo.com.tw.
Abstract:
Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC50 ≤ 5.0 μM).
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