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A Randomized Comparative Effectiveness Trial for Preventing Type 2 Diabetes.

Ronald T Ackermann1, David T Liss1, Emily A Finch1

  • 1Ronald T. Ackermann, David T. Liss, and Emily A. Finch are with the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. Karen K. Schmidt and David G. Marrero are with the Department of Medicine, Indiana University School of Medicine, Indianapolis. Laura M. Hays is with the Indiana University School of Nursing, Indianapolis. Chandan Saha is with the Department of Biostatistics, Indiana University School of Medicine, Indianapolis.

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Summary
This summary is machine-generated.

The YMCA Diabetes Prevention Program (DPP) lifestyle intervention effectively promotes weight loss in low-income adults. This group-based program demonstrated significant weight reduction over 12 months compared to standard care.

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Area of Science:

  • Public Health
  • Preventive Medicine
  • Lifestyle Interventions

Background:

  • The Diabetes Prevention Program (DPP) is a proven intervention for preventing type 2 diabetes.
  • Lifestyle interventions are crucial for managing weight and reducing diabetes risk.
  • Adapting evidence-based programs for community delivery is essential for broad impact.

Purpose of the Study:

  • To evaluate the weight loss effectiveness of a YMCA-administered adaptation of the DPP lifestyle intervention.
  • To compare the YMCA DPP (YDPP) model against standard care for weight loss outcomes.
  • To assess the impact of the YDPP on overweight and obese, low-income adults with elevated glucose levels.

Main Methods:

  • A randomized controlled trial involving 509 overweight/obese, low-income, non-diabetic adults with elevated glucose.
  • Participants were randomized to standard care plus brief counseling or the group-based YDPP.
  • Intention-to-treat and instrumental variable analyses were used to assess weight loss at 12 months.

Main Results:

  • The YDPP group achieved a mean weight loss of 2.3 kg more than the standard care group at 12 months (intention-to-treat).
  • Participants completing 9 or more YDPP lessons showed a greater weight loss of 5.3 kg compared to standard care alone.
  • Adherence rates indicated that 62.6% attended at least one lesson and 40.0% completed 9+ lessons.

Conclusions:

  • The YMCA model for DPP delivery is effective in achieving meaningful weight loss.
  • This community-based lifestyle intervention shows promise for managing weight in vulnerable populations.
  • The YDPP offers a viable approach to diabetes prevention and weight management.