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Ionic liquids in bioanalysis.

Suresh Kumar Kailasa1, Karuna A Rawat1, Hui-Fen Wu2,3

  • 1Department of Applied Chemistry, S V National Institute of Technology, Surat, Gujarat 395007, India.

Bioanalysis
|September 18, 2015
PubMed
Summary
This summary is machine-generated.

Ionic liquids (ILs) offer unique properties as alternatives to organic solvents in analytical chemistry. Their applications in extraction, chromatography, and mass spectrometry for bioassays are rapidly expanding.

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Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Materials Science

Background:

  • Ionic liquids (ILs) are novel solvents composed entirely of ions.
  • ILs exhibit advantageous properties like low volatility, tunable viscosity, and conductivity.
  • There is growing interest in ILs within the analytical and bioanalytical fields.

Purpose of the Study:

  • To review recent advancements in the application of ionic liquids for bioassays.
  • To highlight the use of ILs in sample preparation, separation, and detection techniques.
  • To briefly explore the potential of ILs in biocatalysis.

Main Methods:

  • Literature review of recent publications on ionic liquids in bioanalysis.
  • Focus on ILs as extraction solvents.
  • Discussion of ILs in chromatographic separation and preconcentration.
  • Examination of ILs as matrices in mass spectrometry for bioassays.

Main Results:

  • Ionic liquids show significant promise as versatile solvents in bioanalytical sample preparation.
  • ILs are effective materials for chromatographic separation and preconcentration of analytes.
  • ILs serve as suitable matrices for mass spectrometric bioassays in complex biological samples.

Conclusions:

  • Ionic liquids represent a significant advancement in bioanalytical methodologies.
  • The unique properties of ILs facilitate improved extraction, separation, and detection in bioassays.
  • Further exploration of ILs in biocatalysis is warranted.