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Respiratory Syncytial Virus Preterm (32-36 Completed Weeks of Gestation) Risk Estimation Measure for RSV

Margaret Sheridan-Pereira1, Joan Murphy, Julie Sloan

  • 1From the *Department of Paediatrics and Newborn Medicine, Coombe Women and Infants University Hospital, Dublin; †Department of Paediatrics, Trinity College Dublin, Dublin; ‡National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Crumlin, Dublin; §Department of Pediatrics, Cavan General Hospital, Cavan, Dublin; ¶Children's University Hospital, Dublin; ‖Department of Paediatrics, Cork University Maternity Hospital, Wilton, Cork; **Department of Paediatrics, AMNCH Tallaght Hospital, Dublin; ††Department of Paediatrics, Rotunda Hospital, Dublin; ‡‡Department of Pediatrics, Midlands Regional Hospital, Mullingar; §§Department of Pediatrics, Midlands Regional Hospital, Portlaoise; ¶¶Department of Pediatrics, Mt. Carmel Hospital, Dublin; ‖‖Department of Pediatrics, National Maternity Hospital, Dublin; ***Department of Pediatrics, Our Lady of Lourdes Hospital, Drogheda, Co Louth; †††Department of Pediatrics, South Tipperary General Hospital, Clonmel; ‡‡‡Department of Pediatrics, St. Luke's Hospital, Kilkenny; §§§Department of Pediatrics, Waterford Regional Hospital, Waterford; ¶¶¶Department of Pediatrics, Wexford General Hospital, Wexford, Ireland; ‖‖‖Division of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands; and ****Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.

The Pediatric Infectious Disease Journal
|September 18, 2015
PubMed

Insights

Respiratory syncytial virus hospitalization (RSVH) risk factors in late preterm infants (32-36 weeks GA) in Ireland include neonatal respiratory morbidity and being Caucasian. These findings aid targeted prophylaxis strategies for infants at escalated risk.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Respiratory syncytial virus (RSV) prophylaxis is recommended for late preterm infants at high risk of hospitalization.
  • Country-specific data are crucial for effective, targeted prophylaxis strategies.
  • This study uniquely includes infants born at 36 weeks of gestational age (GA).

Purpose of the Study:

  • To identify independent risk factors for respiratory syncytial virus hospitalization (RSVH) in infants aged 32-36 weeks GA in Ireland.
  • To inform country-specific prophylaxis guidelines for late preterm infants.
  • To analyze risk factors in a population including 36 weeks GA infants.

Main Methods:

  • Prospective observational study conducted across 13 hospitals in Ireland.
  • Recruited non-prophylaxed infants aged 32-36 weeks GA with laboratory-confirmed RSVH.
  • Analyzed baseline and first-year clinical data using logistic regression to determine independent risk factors.

Main Results:

  • The RSVH rate was 3.6% among 1807 analyzed infant records; no RSV-attributable mortality was observed.
  • Five independent risk factors for RSVH were identified: older siblings, being Caucasian, neonatal respiratory morbidity, birth between July 15 and December 15, and family history of asthma.
  • Birth at 36 weeks to 36 + 6 days GA was associated with a reduced risk of RSVH.

Conclusions:

  • Neonatal respiratory morbidity and Caucasian ethnicity are significant population-specific risk factors for RSVH in 32-36 weeks GA infants in Ireland.
  • Identified risk factors largely align with previous international studies.
  • Findings support the need for tailored RSV prophylaxis strategies based on local epidemiological data.
Abstract

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