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Guillain-BarrÉ Syndrome After Immunization in Canadian Children (1996-2012)
Karina A Top1, Shalini Desai, Dorothy Moore
1From the *Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada; †Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada; ‡Division of Infectious Diseases, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; §Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Alberta, Canada; ¶Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada; and ‖The members of the Canadian Immunization Monitoring Program Active are provided in the Appendix.
Abstract:
Guillain-Barré syndrome (GBS) cases admitted to Canadian pediatric tertiary care centers were ascertained through active surveillance. From 1996 to 2012, 246 cases were identified, and 24 (10%) had onset ≤30 days after immunization. Annual rate of postimmunization GBS was 2.0 per 100,000 hospitalizations. Postimmunization GBS was an infrequent cause of pediatric hospitalization.
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