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Statins Increase Plasminogen Activator Inhibitor Type 1 Gene Transcription through a Pregnane X Receptor Regulated

Frederick M Stanley1, Kathryn M Linder2, Timothy J Cardozo1

  • 1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York, United States of America.

Plos One
|September 18, 2015
PubMed
Summary

Statins like atorvastatin activate the PAI-1 promoter by binding to the pregnane X receptor (PXR). This interaction, involving PXR-RXR heterodimers, influences PAI-1 gene expression and has implications for cardiovascular disease.

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