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CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis

Jia-Jun Zhao1, Di Wang1, Hui Yao1

  • 1Jia-Jun Zhao, Di Wang, Hui Yao, Da-Wei Sun, Hong-Yu Li, Department of Gastroenterology, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China.

World Journal of Gastroenterology
|September 18, 2015
PubMed
Summary

Genetic variations in cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and multi-drug resistance 1 (MDR1) genes are associated with an increased risk of ulcerative colitis (UC). Specific single nucleotide polymorphisms (SNPs) in CTLA-4 and MDR1 may contribute to UC development.

Keywords:
Cytotoxic T lymphocyte-associated antigen-4Meta-analysisMulti-drug resistance 1PolymorphismUlcerative colitisrs1045642 C > Trs231775 G > Ars3087243 G > A

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