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Participation of the complement system in ischemia/reperfusion injury
B Rubin1, A Smith, A Romaschin
1Division of Vascular Surgery, R. Fraser Elliott Vascular Research Laboratory, University of Toronto, Ontario, Canada.
Microcirculation, Endothelium, and Lymphatics
|June 1, 1989
Abstract:
Reperfusion of ischemic skeletal muscle is associated with an early infiltration of WBC, a process mediated by locally generated chemotactic factors. We present evidence that selective activation of the alternative complement cascade occurs in response to skeletal muscle ischemia/reperfusion injury. Complement activation may result in the generation of peptides which are chemotactic for neutrophils, and the formation of molecular complexes which injure cell membranes.