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Platelet activating factors are associated with depressive symptoms in coronary artery disease patients: a

Graham Mazereeuw1, Nathan Herrmann2, Hongbin Xu3

  • 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada ; CIHR Training Program in Neurodegenerative Lipidomics, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

Neuropsychiatric Disease and Treatment
|September 18, 2015
PubMed

Insights

Depression in coronary artery disease (CAD) patients may be linked to specific platelet-activating factor (PAF) lipids. Higher levels of certain PAF species in the blood correlated with increased depressive symptom severity in CAD individuals.

Area of Science:

  • Cardiovascular Medicine
  • Neuroscience
  • Biochemistry

Background:

  • Depression frequently complicates coronary artery disease (CAD), but its causes remain unclear.
  • Platelet-activating factor (PAF) lipids, implicated in CAD, are being investigated for their role in depression through mechanisms like inflammation and oxidative stress.

Purpose of the Study:

  • To investigate the association between specific platelet-activating factor (PAF) lipid species and depressive symptom severity in patients with coronary artery disease (CAD).

Main Methods:

  • The study analyzed plasma samples from 26 CAD patients using high-performance liquid chromatography electrospray ionization mass spectrometry.
  • Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HAM-D).

Main Results:

  • Significant positive correlations were found between depressive symptom severity (HAM-D score) and plasma levels of specific PAF species: PC(O-12:0/2:0), PC(O-14:1/2:0), PC(O-17:3/2:0), and PC(O-18:3/2:0).
  • These associations remained significant after adjusting for patient age and sex.

Conclusions:

  • Preliminary findings suggest that the PAF lipidome may hold potential as a source of biomarkers for depressive symptoms in individuals with CAD.
  • Further exploration of PAF lipid species is warranted for understanding and potentially treating depression in CAD patients.
Abstract

Keywords:
biomarkercardiovasculardepressioninflammationlipidomicsoxidative stressvascular depression

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