Related Experiment Video
Updated: Apr 3, 2026
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism is associated with hypertension risk in Asians: a
Kui Jia1, Honglei Wang1, Pingshuan Dong1
1Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan Province, China.
Background:
The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism and hypertension in Asians has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the hypertension risk.
Method:
An electronic literature search was conducted using the following database: PubMed, Embase and China National Knowledge Infrastructure (CNKI) till to Mar 25th, 2015. The strength of the association between statins and fractures risk was calculated with the OR and respective 95% CIs. The random effect model was used.
Results:
Nine studies evaluating the relationship between ALDH2 Glu504Lys polymorphism and hypertension risk in Asians were selected in this meta-analysis. A total of 12161 subjects were included. The data showed that ALDH2 Glu504Lys polymorphism could increase the risk of hypertension of Asians (OR = 1.31; 95% CI, 1.18-1.47; P < 0.00001). In the subgroup analysis of race, both Japanese and Chinese with ALDH2 Glu504Lys polymorphism showed increased hypertension risk (OR = 1.23; 95% CI, 1.09-1.38; P = 0.0006 and OR = 1.46; 95% CI, 1.21-1.77; P = 0.0001), respectively. In the subgroup analysis of gender, males with this polymorphism showed increased hypertension risk (OR = 1.59; 95% CI, 1.40-1.80; P < 0.00001). However, females did not showed this result (OR = 0.94; 95% CI, 0.69-1.30; P = 0.71). When considered alcohol consumption, we found that drinkers and non-drinkers all had increased hypertension risk, if they carried this polymorphism.
Conclusion:
This meta-analysis suggested that ALDH2 Glu504Lys polymorphism was a risk factor of hypertension in Asians.
More Related Videos
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
03:45Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Related Concept Videos
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
01:28Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
01:29Hypertension II: Pathophysiology
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
02:41Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...