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Age-related changes of normal prostate: evaluation by MR diffusion tensor imaging.

Ji Zhang1, Wei-Zhong Tian2, Chun-Hong Hu3

  • 1Department of Radiology, The First Hospital Affiliated to Soochow University Jiangsu Provinece, Suzhou 215006, China ; Department of Radiology, Taizhou People's Hospital Jiangsu Province, Taizhou 225300, China.

International Journal of Clinical and Experimental Medicine
|September 18, 2015
PubMed
Summary

Normal prostate tissue shows age-related changes in diffusion MRI metrics. Fractional Anisotropy (FA) decreases and Apparent Diffusion Coefficient (ADC) increases in the peripheral zone (PZ) with age, unlike the central zone (CZ).

Keywords:
Prostatediffusion tensor imagingmagnetic resonance imaging

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Area of Science:

  • Radiology
  • Medical Imaging
  • Prostate Health

Background:

  • Diffusion MRI metrics, including Fractional Anisotropy (FA) and Apparent Diffusion Coefficient (ADC), are valuable for characterizing tissue microstructure.
  • The prostate gland consists of distinct anatomical zones, the peripheral zone (PZ) and central zone (CZ), which may exhibit different biological properties and age-related changes.

Purpose of the Study:

  • To investigate the age-related differences in FA and ADC values within the peripheral zone (PZ) and central zone (CZ) of the normal prostate.
  • To assess the correlation between these diffusion MRI parameters and age in healthy volunteers.

Main Methods:

  • Fifty healthy male volunteers were stratified into three age groups: 15-30 years, 31-50 years, and >51 years.
  • Diffusion MRI was performed to measure FA and ADC values in the PZ and CZ of the prostate.
  • Statistical analyses, including comparisons between zones and age groups, and Pearson correlation analysis with age, were conducted.

Main Results:

  • Significant differences in FA and ADC values were observed between the PZ and CZ within each age group (P<0.05).
  • In the PZ, FA values decreased significantly with age (0.227±0.052 in young adults to 0.145±0.034 in older adults), while ADC values increased significantly (1.439±0.160×10⁻³ mm²/s to 2.001±0.266×10⁻³ mm²/s).
  • No significant age-related differences in FA or ADC values were found in the CZ.

Conclusions:

  • Diffusion MRI parameters (FA and ADC) in the normal prostate peripheral zone are significantly age-dependent.
  • FA values in the PZ decrease, and ADC values increase with advancing age, indicating microstructural alterations.
  • The central zone of the normal prostate does not exhibit significant age-related changes in FA and ADC values.