Related Experiment Video
Updated: Apr 3, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Retrosplenial Cortex and Long-Term Memory: Molecules to Behavior
Travis P Todd1, David J Bucci1
1Department of Psychological and Brain Sciences, Dartmouth College, Hanover 03755, NH, USA.
Abstract:
The retrosplenial cortex (RSC) is reciprocally connected with the hippocampus and various parahippocampal cortical regions, suggesting that RSC is well-positioned to contribute to hippocampal-dependent memory. Consistent with this, substantial behavioral evidence indicates that RSC is essential for consolidating and/or retrieving contextual and spatial memories. In addition, there is growing evidence that RSC neurons undergo activity-dependent plastic changes during memory formation and retrieval. In this paper we review both the behavioral and cellular/molecular data and posit that the RSC has a particularly important role in the storage and retrieval of spatial and contextual memories perhaps due its involvement in binding together multiple cues in the environment. We identify remaining questions and avenues for future research that take advantage of emerging methods to selectively manipulate RSC neurons both spatially and temporally and to image the RSC in awake, behaving animals.
Related Concept Videos
Role of Cerebellum and Prefrontal Cortex in Memory
Somatosensory, Motor, and Association Cortex
Higher Mental Functions of Brain: Learning and Memory
Role of Hippocampus in Memory
Lobes of the Cerebrum
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
Long-Term Memory
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...

