Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

40
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
40
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

111
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
111
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

72
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
72
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.9K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.9K
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

2.6K
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
2.6K
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

1.3K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infection prevention and control risk assessment and policy for respiratory viral infections in National Health Service trusts in England: a national survey.

The Journal of hospital infection·2026
Same author

Safety and efficacy of CRS3123 in adults with a primary episode or first recurrence of Clostridioides difficile infection: a phase 2, randomised, double-blind, multicentre, vancomycin-controlled study.

The Lancet. Infectious diseases·2026
Same author

Two concurrent nationwide healthcare-associated outbreaks of <i>Burkholderia cepacia</i> complex linked to product contamination, UK and Ireland, 2010-2023 - ADDENDUM.

Infection control and hospital epidemiology·2025
Same author

Understanding the impact of different hand drying methods on viral aerosols formation and surface contamination in indoor environments.

Frontiers in public health·2025
Same author

Two Decades of BSAC Resistance Surveillance.

The Journal of antimicrobial chemotherapy·2025
Same author

Clostridioides difficile pathogenesis and control.

Nature reviews. Microbiology·2025

Related Experiment Video

Updated: Apr 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K

The Control of Methicillin-Resistant Staphylococcus aureus Blood Stream Infections in England.

Brian Duerden1, Carole Fry2, Alan P Johnson3

  • 1Cardiff University Medical School , Heath Park , United Kingdom.

Open Forum Infectious Diseases
|September 18, 2015
PubMed
Summary

England

Keywords:
healthcare-associated infections

More Related Videos

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.3K
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K

Related Experiment Videos

Last Updated: Apr 3, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.3K
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K

Area of Science:

  • Healthcare epidemiology
  • Infectious disease prevention
  • Public health policy

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) pose a significant healthcare challenge with high mortality rates.
  • MRSA BSIs represent a substantial burden in specific healthcare environments.
  • Effective infection control strategies are crucial for managing MRSA prevalence.

Purpose of the Study:

  • To evaluate the impact of a national infection prevention campaign on MRSA BSI rates in England.
  • To identify key components of the successful public health intervention.
  • To offer insights for other healthcare systems facing endemic MRSA.

Main Methods:

  • Analysis of national MRSA BSI data following mandatory reporting implementation in 2001.
  • Appraisal of serial national infection prevention directives and their effectiveness.
  • Assessment of the role of expert improvement teams in achieving reduction targets.

Main Results:

  • Achieved an approximately 80% reduction in MRSA BSIs, exceeding the initial 50% national target.
  • Observed a sustained decline in MRSA BSI rates post-intervention.
  • Demonstrated the success of a comprehensive public health campaign in transforming MRSA from endemic to sporadic.

Conclusions:

  • The national infection prevention campaign in England was highly effective in drastically reducing MRSA BSIs.
  • A multi-faceted public health approach, including directives and potentially other unstated factors, drove significant improvements.
  • Lessons learned from England's experience offer valuable guidance for global healthcare systems combatting MRSA.