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[Tuberculosis among patients in Israel with anti-TNF]
Abstract:
Treatment with anti-TNF increases the rate of the reactivation of latent tuberculosis (TB) infection. We present five case reports of patients who were treated with anti-TNF and developed active TB infection. Physicians should be aware of this possible complication and should conduct screening with the purified protein derivative test (PPD) or the interferon gamma release assay (IGRA) before anti-TNF treatment.
Insights
Anti-tumor necrosis factor (TNF) therapy can increase tuberculosis (TB) reactivation risk. Physicians must screen patients for latent TB using PPD or IGRA tests before initiating anti-TNF treatment to prevent active infection.
Area of Science:
- Immunology
- Infectious Diseases
- Rheumatology
Background:
- Anti-tumor necrosis factor (anti-TNF) therapies are widely used for inflammatory conditions.
- Anti-TNF treatment is associated with an increased risk of opportunistic infections, including tuberculosis (TB).
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