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[Digitalis--selected problems and controversies].

E Nartowicz, B Paczkowska

    Wiadomosci Lekarskie (Warsaw, Poland : 1960)
    |October 1, 1989
    PubMed
    Summary

    Digitalis glycosides are useful for atrial fibrillation and mild heart failure but not recommended for severe stages or acute myocardial infarction. Their role in chronic conditions requires further research against new drugs.

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    Increased plasma glutathione peroxidase activity in patients with acute myocardial infarction.

    Medical science monitor : international medical journal of experimental and clinical research·2001

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Digitalis glycosides have been used for decades in treating cardiovascular conditions.
    • Their precise role in chronic congestive cardiac failure, myocardial infarction, and mitral stenosis remains debated due to varying study methodologies.

    Purpose of the Study:

    • To assess the current utility and place of digitalis glycosides in managing specific cardiovascular diseases.
    • To clarify the effectiveness of digitalis in different stages and etiologies of cardiac failure.

    Main Methods:

    • Review of existing literature and clinical consensus on digitalis glycoside usage.
    • Analysis of hemodynamic parameters and patient qualification criteria in previous studies.

    Main Results:

    • Digitalis glycosides are unequivocally beneficial for cardiac failure with atrial fibrillation and ventricular tachycardia.
    • Effective in mild cardiac failure (NYHA Class I-II), but ineffective in severe stages (NYHA Class IV).
    • Controversial use in acute myocardial infarction, generally not recommended except for specific arrhythmias.

    Conclusions:

    • Digitalis glycosides remain valuable for specific arrhythmias and mild heart failure.
    • Their use in acute myocardial infarction is limited.
    • Future role depends on comparative studies with novel positive inotropic agents.

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