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Leptin/adiponectin ratio predicts poststroke neurological outcome.
Federico Carbone1, Fabienne Burger1, Gloria Roversi2
1Division of Cardiology, Foundation for Medical Researches, Department of Medical Specialties, Geneva University, Geneva, Switzerland.
European Journal of Clinical Investigation
|September 19, 2015
Summary
Higher leptin/adiponectin ratio in acute ischemic stroke (AIS) patients predicts better neurological recovery and may indicate hemorrhagic transformation risk. This finding highlights adipokines as potential prognostic biomarkers for post-stroke brain injury.
Area of Science:
- Endocrinology
- Neurology
- Cardiovascular Research
Background:
- Adipokines are linked to atherosclerotic plaque rupture and cardiovascular events like acute ischemic stroke (AIS).
- The role of adipokines in post-stroke brain injury remains largely unexplored.
Purpose of the Study:
- To investigate the predictive value of the serum leptin/adiponectin ratio for neurological recovery at 90 days post-AIS.
- To assess the predictive value of serum adipokine levels for clinical and radiological outcomes within 7 days after AIS.
Main Methods:
- Substudy analysis of 35 nonobese patients with first atherothrombotic stroke.
- Evaluation of serum leptin and adiponectin levels, leptin/adiponectin ratio.
- Assessment of neurological recovery using NIHSS and mRS, and radiological outcomes including lesion volume and hemorrhagic transformation (HT).
Main Results:
- Elevated serum leptin and leptin/adiponectin ratio at day 1 post-AIS correlated inversely with clinical and radiological parameters.
- Higher circulating leptin predicted improved neurological recovery at 90 days.
- The leptin/adiponectin ratio predicted HT occurrence within 7 days (adjusted OR 0.15; P = 0.030) and remained significant after adjustments.
Conclusions:
- A higher leptin/adiponectin ratio on day 1 post-atherothrombotic AIS predicts better neurological outcomes.
- This ratio may serve as a valuable prognostic biomarker for atherothrombotic stroke patients.
