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Updated: Apr 3, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Corneal Collagen Cross-linking: A Review of Clinical Applications
Kunyong Xu1, Tommy C Y Chan, Rasik B Vajpayee
1From the *Department of Ophthalmology, Queen's University, Kingston, Canada; †Department of Ophthalmology, Hotel Dieu and Kingston General Hospitals, Kingston, Canada; ‡Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong; §Hong Kong Eye Hospital, Hong Kong; ¶Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia; ∥Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre University of Melbourne, Melbourne, Australia; and **Department of Ophthalmology, Prince of Wales Hospital, Hong Kong.
Abstract:
Corneal collagen cross-linking (CXL) has been shown to slow down or stop the progression of keratoconus. In addition, CXL has been applied in cases of corneal ectasia. Recent reports of the use of CXL in cases of infectious keratitis have generated further interest in this treatment modality. This review discusses the principle, clinical uses, and complications associated with CXL.
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