Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

14.1K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.1K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.8K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.6K
9.6K
Bone Remodeling01:40

Bone Remodeling

41.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-Dimensional-Printed Polylactic Acid Scaffolds Coated With a Paeonol-Incorporated Gelatin/Bioactive Glass Composite Layer for Enhanced Osteogenic Performance.

Biotechnology and bioengineering·2026
Same author

Results of an Ultra Short Metaphyseal Filling Cementless Stem in Primary Total Hip Arthroplasty: Mean 12.1-Year Follow-up.

Indian journal of orthopaedics·2026
Same author

Comparing Anterior Versus Posterior Size Referencing in Patients Undergoing Simultaneous Bilateral Total Knee Arthroplasty: One Technique Per Knee.

Indian journal of orthopaedics·2026
Same author

Stress detection using time-frequency analysis and machine learning framework.

Biomedical physics & engineering express·2025
Same author

Does preoperative varus alignment impact functional outcomes in robotic assisted medial unicompartmental knee arthroplasty? mid-term analysis.

Journal of robotic surgery·2025
Same author

Robotic assisted fixed bearing medial UKA: can soft tissue balancing and restoration of alignment modify PFJ kinematics in the presence of chondral wear.

The Knee·2025
Same journal

Correction to: Hip Arthroscopy After Total Hip Arthroplasty: A Current Review of Indications, Techniques, and Outcomes.

Current reviews in musculoskeletal medicine·2026
Same journal

Parsing Through the Data on Achilles Tendon Rupture Management, Rehab and Sports Return Criteria: a Current Literature Review.

Current reviews in musculoskeletal medicine·2026
Same journal

Perioperative Management of Patients Undergoing Periacetabular Osteotomy: An Evidence-Based Review.

Current reviews in musculoskeletal medicine·2026
Same journal

Osteonecrosis of the Femoral Head: Evolution of Contemporary Management Strategies.

Current reviews in musculoskeletal medicine·2026
Same journal

The Management of Acetabular Labral Tears: A Contemporary Review.

Current reviews in musculoskeletal medicine·2026
Same journal

To Trim or Not to Trim: Revisiting Acetabuloplasty During Hip Arthroscopy for Femoroacetabular Impingement and Acetabular Overcoverage.

Current reviews in musculoskeletal medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.0K

Osteochondral autografts.

Shantanu Patil1, Sachin R Tapasvi2

  • 1The Orthopaedic Speciality Clinic, 16 Status Chambers, 1221/A Wrangler Paranjpe Road, Pune, 411004, India. shantanusp@gmail.com.

Current Reviews in Musculoskeletal Medicine
|September 19, 2015
PubMed
Summary
This summary is machine-generated.

Articular cartilage repair is challenging due to limited healing potential. For large osteochondral defects (>2 cm), the osteochondral autograft technique shows excellent short-term results for sustained recovery.

Keywords:
Cartilage repairOsteochondral autograftTidemark

More Related Videos

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Related Experiment Videos

Last Updated: Apr 3, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

18.0K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Articular cartilage lesions have limited spontaneous healing capacity due to physiological, mechanical, and local factors.
  • Partial- and full-thickness cartilage injuries result in slow, often non-durable tissue responses.
  • Subchondral bone damage leads to fibrocartilage formation, which is prone to long-term failure under cyclic loading.

Purpose of the Study:

  • To evaluate the efficacy of the osteochondral autograft technique for treating large osteochondral defects.
  • To provide a definitive treatment for symptomatic, high-demand patients requiring sustained recovery.
  • To explore options for repairing osteochondral defects with hyaline cartilage.

Main Methods:

  • The study involved treating osteochondral defects larger than 2 cm using the osteochondral autograft technique.
  • Patient selection focused on symptomatic individuals with high functional demands.
  • Short-term outcomes of the treated cases were assessed.

Main Results:

  • The osteochondral autograft technique demonstrated excellent short-term outcomes in the studied patient series.
  • This method facilitates repair of osteochondral defects, aiming for hyaline cartilage regeneration.
  • The technique offers a potential solution for sustained recovery with minimal debilitation.

Conclusions:

  • The osteochondral autograft technique is a viable and effective option for managing large osteochondral defects (>2 cm).
  • This approach shows promise for achieving durable repair and restoring function in patients with significant cartilage injuries.
  • Further research may explore long-term efficacy and compare with other treatment modalities.