Y STR haplotype diversity in central Indian population

Area of Science:

• Population genetics
• Forensic genetics
• Human population studies

Background:

• Understanding genetic diversity within populations is crucial for anthropological and forensic applications.
• The Y-chromosome Short Tandem Repeat (Y-STR) loci are valuable markers for studying paternal lineage and population genetics.
• Limited Y-STR data exists for the central Indian population, necessitating further research.

Purpose of the Study:

• To analyze genetic diversity at 17 Y-STR loci in 173 males from central India.
• To establish a population-specific Y-STR database for forensic and anthropological applications.
• To compare central Indian Y-STR profiles with other global populations.

Main Methods:

• Genotyping of 17 Y-STR loci using the AmpFlSTR® Yfiler® Kit and capillary electrophoresis.
• Calculation of allele frequencies, gene diversity, and haplotype diversity.
• Comparison of obtained haplotype data with the Y-STR Haplotypes Reference Database (YHRD) and other published data using AMOVA and MDS plots.

Main Results:

• A total of 147 haplotypes were observed, with 125 being unique, indicating high genetic variability.
• Haplotype diversity was 0.9979, and the discriminating capacity was 0.8497.
• Gene diversity at the analyzed loci ranged from 0.398 to 0.785, with DYS385a/b showing a genotype diversity of 0.869.

Conclusions:

• The central Indian population exhibits significant genetic differentiation compared to other Indian and international populations.
• The generated Y-STR data provides a valuable resource for forensic casework, anthropological research, and demographic studies in India.
• This study highlights the importance of population-specific genetic data for accurate forensic identification and understanding human migration patterns.