Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triclosan: a safety profile.

S J DeSalva, B M Kong, Y J Lin

    American Journal of Dentistry
    |September 1, 1989
    PubMed
    Summary

    Triclosan, an antimicrobial agent, is safe for use in oral care products like toothpaste. Extensive safety reviews, including pre-clinical and clinical studies, show it is well-tolerated by humans with minimal absorption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Impact of tirofiban on outcomes in STEMI patients across different levels of inflammation: a stratified analysis based on complete blood count-derived inflammatory markers].

    Zhonghua xin xue guan bing za zhi·2026
    Same author

    [A real-world study on the features of postpartum hepatitis flares in pregnant women with chronic HBV infection].

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2024
    Same author

    [Research progress of polyetheretherketone and its composites in the field of dental implant].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2022
    Same author

    [Modified mattress inversion suturing with double barbed sutures used for totally laparoscopic esophagojejunostomy overlap anastomosis after radical total gastrectomy].

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2022
    Same author

    [Cone-beam CT analysis of the correlation between incisor root resorption rate and tooth movement index in adult patients with fixed orthodontics appliance].

    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2022
    Same author

    [Tracing investigation and analysis of a <i>Clostridium botulinum</i> food poisoning incident in Bayingolin Mongolian Autonomous Prefecture, Xinjiang].

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2022

    Area of Science:

    • Toxicology
    • Pharmacology
    • Dermatology

    Background:

    • Triclosan (2, 4, 4'-trichloro-2'-hydroxydiphenyl ether) is a widely used antimicrobial agent in consumer products for two decades.
    • Its application has recently expanded to oral hygiene products, including dentifrices.

    Purpose of the Study:

    • To comprehensively review existing safety data for triclosan, focusing on its use in oral health products.
    • Evaluate pre-clinical and clinical studies, regulatory submissions, and internal company research.

    Main Methods:

    • Review of acute, subacute, subchronic, and chronic toxicity studies.
    • Assessment of mutagenicity, carcinogenicity, reproduction/teratology, and pharmacokinetic data.
    • Analysis of clinical trial data from triclosan dentifrice and mouthrinse usage.

    Main Results:

    • Triclosan demonstrated good tolerability across various species, including humans.
    • Clinical studies indicated a steady state by day 7, with blood levels in the parts per billion (ppb) range.
    • Urine was identified as the primary route of triclosan excretion.

    Conclusions:

    • Based on extensive safety evaluations, triclosan is considered safe for incorporation into dentifrice and mouthrinse formulations.
    • The reviewed data supports the safe use of triclosan in oral care products.

    Related Experiment Videos