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Updated: Apr 3, 2026

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FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
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Prenatal diagnosis and obstetric management
Pat O'Brien1, Mae Nugent2, Asma Khalil3
1Institute for Women's Health, University College London Hospitals, London NW1, UK.
Seminars in Pediatric Surgery
|September 19, 2015
Summary
Accurate prenatal diagnosis of conjoined twins enables informed parental decisions regarding pregnancy management and delivery. Early detection by multidisciplinary teams improves outcomes for these rare births.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Neonatology
Background:
- Conjoined twins are rare, occurring in 1 in 50,000 to 200,000 live births, with generally poor prognoses.
- Accurate prenatal diagnosis is crucial for effective management and parental counseling.
Purpose of the Study:
- To emphasize the importance of accurate prenatal diagnosis for conjoined twins.
- To outline the implications of diagnosis for pregnancy management and delivery planning.
Main Methods:
- Multidisciplinary team approach.
- Utilizing a combination of advanced imaging modalities for diagnosis.
- Early gestational age diagnosis.
Main Results:
- Prenatal diagnosis empowers parents with informed choices regarding pregnancy.
- Options include termination, palliative care, or planned intensive care and separation.
- Cesarean section is the recommended delivery method to minimize risks.
Conclusions:
- Early and accurate prenatal diagnosis of conjoined twins is essential.
- Informed decision-making by parents is facilitated by expert multidisciplinary teams.
- Cesarean delivery is critical for optimizing outcomes for both mother and conjoined twins.
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