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Updated: Apr 3, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
Published on: July 14, 2017
Model for calcium-mediated reduction of structural fluctuations in epidermis
Yasuaki Kobayashi1,2, Hiroyuki Kitahata3, Masaharu Nagayama1,2
1Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan.
Abstract:
We propose a reaction-advection-diffusion model of epidermis consisting of two variables, the degree of differentiation and the calcium ion concentration, where calcium ions enhance differentiation. By analytically and numerically investigating this system, we show that a calcium localization layer formed beneath the stratum corneum helps reduce spatiotemporal fluctuations of the structure of the stratum corneum. In particular, spatially or temporally small-scale fluctuations in the lower structure are suppressed and do not affect the upper structure, due to acceleration of differentiation by calcium ions. Analytical expressions for the reduction rate of fluctuation amplitudes are shown.
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