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Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications
Published on: October 5, 2018
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Ultrasound-induced inertial cavitation from gas-stabilizing nanoparticles
J J Kwan1, S Graham1, R Myers1
1Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|September 19, 2015
Summary
Researchers developed tunable nanocups to control nanobubble size for cavitation applications. This breakthrough allows precise prediction and manipulation of nanobubble behavior, advancing fields like cancer therapy.
Area of Science:
- Nanotechnology
- Acoustic cavitation
- Materials science
Background:
- Understanding nanoparticle cavitation is limited by the inability to control nanobubble size.
- Cavitation from nanoparticles plays a crucial role in various scientific and medical applications.
Purpose of the Study:
- To present a novel method for manufacturing nanoparticles with tunable hemispherical depressions (nanocups).
- To enable precise control over nanobubble size and predict cavitation behavior.
Main Methods:
- Fabrication of nanoparticles with tunable single hemispherical depressions (nanocups) of specific mean diameters (90, 260, 650 nm).
- Utilizing a modified Rayleigh-Plesset crevice model to predict inertial cavitation thresholds.
- Experimental verification of the model's predictions.
Main Results:
- Successful manufacturing of nanocups with controlled nanobubble entrapment.
- Demonstrated correlation between nanocavity size, frequency, and inertial cavitation threshold.
- Experimental validation of the predictive model.
Conclusions:
- The developed nanocups offer a method to tune cavitation nanonuclei.
- Predictive modeling and experimental validation enable control over nanobubble behavior.
- This technology has potential applications in cancer therapy and ultrasonic cleaning.
