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Updated: Apr 3, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation
Maro Ohanian1, Carlos Bueso-Ramos2, Chi Young Ok2
1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abstract:
Little is known about MYC dysregulation in myeloid malignancies, and the authors were unable to find published studies that evaluated MYC protein expression in primary cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Herein, we describe the clinical, morphologic, immunophenotypic, cytogenetic, and molecular genetic findings in two MDS/AML cases that contained both MYC rearrangement and the JAK2 V617F mutation. We also demonstrate MYC protein expression by immunohistochemistry in both patients.
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