Officinalioside, a new lignan glucoside from Borago officinalis L
Mamdouh Nabil Samy1,2, Ashraf Nageeb El-Sayed Hamed2, Sachiko Sugimoto1
1a Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences , Hiroshima University , Hiroshima , Japan.
Abstract:
A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM).
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