Related Experiment Video
Updated: Apr 3, 2026

09:27
Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
Published on: April 22, 2016
18.3K
Biotechnological applications of microbial bioconversions
Carrie Perkins1, Sana Siddiqui2, Munish Puri3
1a Morningside Translations , New York , NY , USA.
Critical Reviews in Biotechnology
|September 19, 2015
Summary
Microbial transformation utilizes diverse microbial reactions to create novel therapeutic and industrial compounds from organic matter. This biotransformation process yields valuable metabolites for the pharmaceutical and biotechnology sectors.
Area of Science:
- Biotechnology
- Microbiology
- Organic Chemistry
Background:
- Modern research extensively explores microbial transformation of organic compounds.
- Microbial transformation offers a versatile approach for synthesizing new chemical entities.
- Natural products serve as a rich source for biotransformation strategies.
Purpose of the Study:
- To review the production of important compounds via microbial biotransformation.
- To highlight metabolites relevant to the pharmaceutical and biotechnological industries.
- To discuss practical considerations in microbial transformation processes.
Main Methods:
- Literature review of microbial transformation studies.
- Analysis of biotransformation pathways and enzymatic reactions.
- Identification and characterization of microbial metabolites.
Main Results:
- Numerous compounds of therapeutic and industrial interest are produced through microbial biotransformation.
- Specific metabolites with significant pharmaceutical and biotechnological potential have been identified.
- The versatility of microbial enzymes enables a wide range of chemical modifications.
Conclusions:
- Microbial transformation is a powerful and sustainable method for generating valuable compounds.
- The pharmaceutical and biotechnology industries can benefit greatly from applied biotransformation techniques.
- Further research into microbial metabolic capabilities will unlock new compound discoveries.
Related Concept Videos
Environmental Applications of Microorganisms
1.5K
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
1.5K
Bioreactor Controls-III
52
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
52
Bioremediation
23.0K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
23.0K
Synthetic Biology
5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
5.8K
Microbial Bioremediation of Hydrocarbons
63
Bioremediation is an environmentally sustainable process that employs living organisms—primarily microorganisms—to degrade or neutralize pollutants from contaminated environments. In oil spills and hydrocarbon pollution, bioremediation involves the use of hydrocarbon-degrading bacteria to transform toxic compounds into less harmful substances. This approach leverages natural microbial metabolic processes and is considered both cost-effective and ecologically favorable compared to...
63
Microbial Biosensors
51
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
51

