Related Experiment Video
Updated: Apr 3, 2026

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
Published on: June 17, 2022
STAT5 gene polymorphisms are associated with the response of acute myeloid leukemia patients to Ara-C-based
Peipei Xu1, Di Zhou1, Jian Ouyang1
1a Department of Hematology , The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
Abstract:
The constitutive activation of signal transducer and activator of transcription 5 (STAT5) occurs during the transformation of fusion genes in leukemia. We aimed to investigate whether or not the genetic polymorphisms in the STAT5 gene are associated with the treatment outcomes of Ara-C-based chemotherapy regimens in patients with acute myeloid leukemia (AML). A total of 152 patients with AML were included in our study. Peripheral blood samples were analyzed through matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Results showed that the frequency of rs2293157 T/T was higher in the complete remission and partial remission groups after Ara-C-based chemotherapy even though the genotype had a high frequency in the intermediate risk groups (p < 0.05). We concluded that rs2293157 is an important marker for the therapeutic efficiency of Ara-C-based chemotherapy in patients with AML, especially in the Chinese population.
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

