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Updated: Apr 3, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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GDF-5 can act as a context-dependent BMP-2 antagonist

Uwe Klammert1, Thomas D Mueller2, Tina V Hellmann3

  • 1Lehrstuhl für Mund-, Kiefer- und plastische Gesichtschirurgie, Universitätsklinikum Würzburg, Pleicherwall 2, 97070, Würzburg, Germany. Klammert_U@klinik.uni-wuerzburg.de.

BMC Biology
|September 20, 2015
PubMed
Summary

Growth differentiation factor (GDF)-5 and bone morphogenetic protein (BMP)-2 have distinct signaling roles despite sharing receptors. A GDF-5 mimic (GDF-5 R57A) antagonized BMP-2 activity, suggesting a GDF-5-specific co-receptor influences signaling outcomes.

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