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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Stem Cell Therapy: Current Applications and Potential for Urology.

Bridget Wiafe1, Peter D Metcalfe2, Adetola B Adesida3

  • 13-007 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada, T6G 2E1. wiafe@ualberta.ca.

Current Urology Reports
|September 20, 2015
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for chronic conditions by aiding tissue repair and reducing inflammation. Urology has seen success, but more research is needed to increase clinical use of stem cells.

Keywords:
Bladder obstructionImmunomodulationMesenchymalRenal fibrosisStem cellsUrinary incontinence

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Area of Science:

  • Regenerative Medicine
  • Urology

Background:

  • Stem cell therapy offers revolutionary potential for chronic conditions.
  • Stem cells possess properties like homing to injury sites, promoting tissue regeneration, and modulating immune responses.
  • Urology has demonstrated significant experimental success with stem cell applications.

Purpose of the Study:

  • To review current efforts in stem cell therapy for urological conditions.
  • To identify barriers and propose strategies for increasing clinical translation of stem cell therapies.

Main Methods:

  • Literature review of experimental and clinical studies in stem cell therapy for urological conditions.
  • Analysis of stem cell mechanisms relevant to urological tissue repair and regeneration.

Main Results:

  • High experimental success rates in urological stem cell therapy.
  • A notable gap exists between experimental success and clinical application rates.

Conclusions:

  • Stem cell therapy is a promising avenue for treating chronic urological diseases.
  • Further research and strategic planning are essential to bridge the gap between experimental findings and widespread clinical adoption.